Detalhe da pesquisa
1.
Oral gepotidacin versus nitrofurantoin in patients with uncomplicated urinary tract infection (EAGLE-2 and EAGLE-3): two randomised, controlled, double-blind, double-dummy, phase 3, non-inferiority trials.
Lancet
; 403(10428): 741-755, 2024 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38342126
2.
Novel Bacterial Topoisomerase Inhibitor Gepotidacin Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats.
Antimicrob Agents Chemother
; 66(11): e0048322, 2022 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36255258
3.
Fitness of real-world data for clinical trial data collection: Results and lessons from a HARMONY Outcomes ancillary study.
Clin Trials
; 19(6): 655-664, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35876156
4.
Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial.
Lancet
; 392(10157): 1519-1529, 2018 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30291013
5.
Harmony Outcomes: A randomized, double-blind, placebo-controlled trial of the effect of albiglutide on major cardiovascular events in patients with type 2 diabetes mellitus-Rationale, design, and baseline characteristics.
Am Heart J
; 203: 30-38, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30015066
6.
Improving clinical trials for cardiovascular diseases: a position paper from the Cardiovascular Round Table of the European Society of Cardiology.
Eur Heart J
; 37(9): 747-54, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26077039
7.
Efficacy and Safety of Gepotidacin as Treatment of Uncomplicated Urogenital Gonorrhea (EAGLE-1): Design of a Randomized, Comparator-Controlled, Phase 3 Study.
Infect Dis Ther
; 12(9): 2307-2320, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37751016
8.
Impact of the 2019 Food and Drug Administration Guidance for Uncomplicated Urinary Tract Infection on Treatment Response Rates: A Reanalysis of a Clinical Trial of Nitrofurantoin vs Fosfomycin.
Open Forum Infect Dis
; 10(11): ofad557, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-38023546
9.
Design of Two Phase III, Randomized, Multicenter Studies Comparing Gepotidacin with Nitrofurantoin for the Treatment of Uncomplicated Urinary Tract Infection in Female Participants.
Infect Dis Ther
; 11(6): 2297-2310, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36271314
10.
The use of electronic health records for recruitment in clinical trials: a mixed methods analysis of the Harmony Outcomes Electronic Health Record Ancillary Study.
Trials
; 22(1): 465, 2021 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34281607
11.
Randomized 52-week Phase 2 Trial of Albiglutide Versus Placebo in Adult Patients With Newly Diagnosed Type 1 Diabetes.
J Clin Endocrinol Metab
; 105(6)2020 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32219329
12.
Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes: A Framework for Evaluating Stratification Using Routine Clinical and Individual Trial Data.
Diabetes Care
; 41(9): 1844-1853, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30072404
13.
Electronic health records to facilitate clinical research.
Clin Res Cardiol
; 106(1): 1-9, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27557678
14.
New medicinal products for chronic heart failure: advances in clinical trial design and efficacy assessment.
Eur J Heart Fail
; 19(6): 718-727, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28345190
15.
Relative bioavailability and the effect of meal type and timing on the pharmacokinetics of migalastat in healthy volunteers.
Clin Pharmacol Drug Dev
; 4(3): 193-202, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-27140799
16.
Effect of darapladib treatment on endarterectomy carotid plaque lipoprotein-associated phospholipase A2 activity: a randomized, controlled trial.
PLoS One
; 9(2): e89034, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24586490
17.
The pharmacological treatment of primary aldosteronism.
Expert Opin Pharmacother
; 7(5): 563-73, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16553572